Background: Although still relatively new, peptides have recently become popular as performance enhancing drugs. GHRP-6 is currently available from a few research companies.
Action: The major side effect accompanied by the use of GHRP-6 is a significant increase in appetite due to a stimulating the release of Ghrelin, a peptide which is released naturally in the lining of the stomach and increases hunger and gastric emptying.
GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, when natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH. GHRP-6 also affects the central nervous system, by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.
Benefits of increased Growth Hormone levels through GHRP-6 stimulation include: an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the primary anabolic mechanism of action for Growth Hormone.
Technical Data: It has also been discovered that when GHRP-6 and insulin are used simultaneously, GH response to GHRP-6 is increased (1). A recent study in normal mice showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function in the mice being administered the GHRP-6 (2). There are still many questions regarding this fairly new compound, scientists are hoping with to gain a better clinical understanding of the peptide through further research over the next few years.